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《医学前沿(英文)》 2018年 第12卷 第3期 页码 289-300 doi: 10.1007/s11684-017-0550-7
Silver-containing preparations are widely used in the management of skin wounds, but the effects of silver ions on skin wound healing remain poorly understood. This study investigated the effects of silver ions (Ag+) on the proliferation of human skin keratinocytes (HaCaT) and the production of intracellular reactive oxygen species (ROS). After treating HaCaT cells with Ag+and/or the active oxygen scavenger N-acetyl cysteine (NAC), cell proliferation and intracellular ROS generation were assessed using CCK-8 reagent and DCFH-DA fluorescent probe, respectively. In addition, 5-bromo-2-deoxyUridine (BrdU) incorporation assays, cell cycle flow cytometry, and proliferating cell nuclear antigen (PCNA) immunocytochemistry were conducted to further evaluate the effects of sub-cytotoxic Ag+ concentrations on HaCaT cells. The proliferation of HaCaT cells was promoted in the presence of 10−6 and 10−5 mol/L Ag+ at 24, 48, and 72 h. Intracellular ROS generation also significantly increased for 5–60 min after exposure to Ag+. The number of BrdU-positive cells and the presence of PCNA in HaCaT cells increased 48 h after the addition of 10−6 and 10−5 mol/L Ag+, with 10−5 mol/L Ag+ markedly increasing the cell proliferation index. These effects of sub-cytotoxic Ag+ concentrations were repressed by 5 mmol/L NAC. Our results suggest that sub-cytotoxic Ag+ concentrations promote the proliferation of human keratinocytes and might be associated with a moderate increase in intracellular ROS levels. This study provides important experimental evidence for developing novel silver-based wound agents or dressings with few or no cytotoxicity.
关键词: ionic silver human keratinocyte cell proliferation reactive oxygen species active oxygen scavenger NAC
Challenges of human–machine collaboration in risky decision-making
《工程管理前沿(英文)》 2022年 第9卷 第1期 页码 89-103 doi: 10.1007/s42524-021-0182-0
关键词: human–machine collaboration risky decision-making human–machine team and interaction task allocation human–machine relationship
Zooming in and out of ferroptosis in human disease
《医学前沿(英文)》 2023年 第17卷 第2期 页码 173-206 doi: 10.1007/s11684-023-0992-z
关键词: ferroptosis human disease iron metabolism lipid peroxidation antioxidation
Dan DAI, Jing LIU
《能源前沿(英文)》 2012年 第6卷 第3期 页码 210-226 doi: 10.1007/s11708-012-0200-3
关键词: human energy harvesting human-powered transportation human-powered home appliances human-powered grid (HPG) human-powered charger (HPC) human-powered storage (HPS) biofuel
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《医学前沿(英文)》 2015年 第9卷 第1期 页码 20-29 doi: 10.1007/s11684-014-0371-x
Ischemic stroke is a focal cerebral insult that often leads to many adverse neurological complications severely affecting the quality of life. The prevalence of stroke is increasing throughout the world, while the efficacy of current pharmacological therapies remains unclear. As a neuroregenerative therapy, the implantation of human umbilical cord mesenchymal stem cells (hUC-MSCs) has shown great possibility to restore function after stroke. This review article provides an update role of hUC-MSCs implantation in the treatment of ischemic stroke. With the unique “immunosuppressive and immunoprivilege” property, hUC-MSCs are advised to be an important candidate for allogeneic cell treatment. Nevertheless, most of the treatments are still at primary stage and not clinically feasible at the current time. Several uncertain problems, such as culture conditions, allograft rejection, and potential tumorigenicity, are the choke points in this cellular therapy. More preclinical researches and clinical studies are needed before hUC-MSCs implantation can be used as a routinely applied clinical therapy.
关键词: cellular therapy transplantation human umbilical cord mesenchymal stem cells ischemic stroke
Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection:
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《医学前沿(英文)》 2017年 第11卷 第4期 页码 480-489 doi: 10.1007/s11684-017-0594-8
Superinfection is frequently detected among individuals infected by human immunodeficiency virus type I (HIV-1). Superinfection occurs at similar frequencies at acute and chronic infection stages but less frequently than primary infection. This observation indicates that the immune responses elicited by natural HIV-1 infection may play a role in curb of superinfection; however, these responses are not sufficiently strong to completely prevent superinfection. Thus, a successful HIV-1 vaccine likely needs to induce more potent and broader immune responses than those elicited by primary infection. On the other hand, potent and broad neutralization responses are more often detected after superinfection than during monoinfection. This suggests that broadly neutralizing antibodies are more likely induced by sequential immunization of multiple different immunogens than with only one form of envelope glycoprotein immunogens. Understanding why the protection from superinfection by immunity induced by primary infection is insufficient and if superinfection can lead to cross-reactive immune responses will be highly informative for HIV-1 vaccine design.
关键词: human immunodeficiency virus type I superinfection incidence immune response
An experimental analysis of human straight walking
Tao LI, Marco CECCARELLI
《机械工程前沿(英文)》 2013年 第8卷 第1期 页码 95-103 doi: 10.1007/s11465-013-0357-4
In this paper, an experimental analysis of human straight walking has been presented. Experiments on human walking were carried out by using Cassino tracking system which is a passive cable-based measuring system. This system is adopted because it is capable of both pose and wrench measurements with fairly simple monitoring of operation. By using experimental results, trajectories of a human limb extremity and its posture have been analyzed; forces that are exerted against cables by the limb of a person under test have been measured by force sensors as well. Furthermore, by using experimental tests, modeling and characterization of the human straight walking gait have been proposed.
关键词: human locomotion walking gait characterization humanoid robot biped robot
《环境科学与工程前沿(英文)》 2022年 第16卷 第10期 doi: 10.1007/s11783-022-1541-8
● Perfluorooctanesulfonic acid and perfluorooctanoic acid highest in human milk.
关键词: Human biomonitoring Human breast milk LC-MS/MS analysis Lifestyle parameters
Glorious Missions Assigned by the Human History
Jian Song
《工程管理前沿(英文)》 2014年 第1卷 第1期 页码 1-1 doi: 10.15302/J-FEM-2014001
An experimental characterization of human torso motion
Daniele CAFOLLA,I-Ming CHEN,Marco CECCARELLI
《机械工程前沿(英文)》 2015年 第10卷 第4期 页码 311-325 doi: 10.1007/s11465-015-0352-z
The torso plays an important role in the human-like operation of humanoids. In this paper, a method is proposed to analyze the behavior of the human torso by using inertial and magnetic sensing tools. Experiments are conducted to characterize the motion performance of the human torso during daily routine operations. Furthermore, the forces acting on the human body during these operations are evaluated to design and validate the performance of a humanoid robot.
关键词: experimental biomechanics human torso analysis inertial sensor characterization
《环境科学与工程前沿(英文)》 2021年 第15卷 第3期 doi: 10.1007/s11783-020-1356-4
•Bacterial concentrations from eight stages were 104–105copies/m3.
关键词: Size distribution Airborne bacteria Biological diversity Human pathogenic bacteria Composting plants
杨孟琢
《中国工程科学》 2002年 第4卷 第8期 页码 12-19
核电人因工程是核工程技术的一个组成部分,是研究人机交互作用,把人的特点引入核电工程设计,获得安全和高效的工艺设备与系统的新兴工程技术领域。结合我国走过的道路,重点论述了核电人因工程领域的形成、进展以及发展方向,同时也介绍了作者提出的人的可靠性的综合分类理论和其它研究成果。
Methodological challenges to human medical study
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《医学前沿(英文)》 2014年 第8卷 第3期 页码 328-336 doi: 10.1007/s11684-014-0359-6
With the transformation of modern medicinal pattern, medical studies are confronted with methodological challenges. By analyzing two methodologies existing in the study of physical matter system and information system, the article points out that traditional Chinese medicine (TCM), especially the treatment based on syndrome differentiation, embodies information conception of methodological positions, while western medicine represents matter conception of methodological positions. It proposes a new way of thinking about combination of TCM and western medicine by combinating two kinds of methodological methods.
关键词: medical paradigm traditional Chinese medicine western medicine scientific view scientific methodology
Hip-mounted electromagnetic generator to harvest energy from human motion
Dan DAI,Jing LIU
《能源前沿(英文)》 2014年 第8卷 第2期 页码 173-181 doi: 10.1007/s11708-014-0301-2
关键词: human power harvesting pervasive energy electricity generation wearable energy renewable and sustainable energy mobile electronics
Wearable thermal energy harvester powered by human foot
Guodong XU, Yang YANG, Yixin ZHOU, Jing LIU
《能源前沿(英文)》 2013年 第7卷 第1期 页码 26-38 doi: 10.1007/s11708-012-0215-9
关键词: human power thermal energy energy harvesting micro power wearable device
标题 作者 时间 类型 操作
Sub-cytotoxic concentrations of ionic silver promote the proliferation of human keratinocytes by inducing
null
期刊论文
Tackling global electricity shortage through human power: Technical opportunities from direct or indirectutilizations of the pervasive and green human energy
Dan DAI, Jing LIU
期刊论文
Implantation of human umbilical cord mesenchymal stem cells for ischemic stroke: perspectives and challenges
null
期刊论文
Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection:
null
期刊论文
Perfluoroalkane acids in human milk under the global monitoring plan of the Stockholm Convention on Persistent
期刊论文
An experimental characterization of human torso motion
Daniele CAFOLLA,I-Ming CHEN,Marco CECCARELLI
期刊论文
The size distribution of airborne bacteria and human pathogenic bacteria in a commercial composting plant
期刊论文